The Proinflammatory Mediators C3a and C5a Are Essential for Liver Regeneration
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چکیده
منابع مشابه
The Proinflammatory Mediators C3a and C5a Are Essential for Liver Regeneration
Complement has been implicated in liver repair after toxic injury. Here, we demonstrate that complement components are essential for liver regeneration, and mediate their effect by interacting with key signaling networks that promote hepatocyte proliferation. C3- or C5-deficient mice exhibited high mortality, parenchymal damage, and impaired liver regeneration after partial hepatectomy. Mice wi...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2003
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20030374